Sexual dimorphism in autoimmunity
نویسندگان
چکیده
منابع مشابه
Sexual Dimorphism
S Vertebrates ” ( J. G. M. Thewissen , and S. Nummela , eds ) , pp. 211 – 224 . University of California Press , Berkeley . Pihlström , H. ( 2008 ). Comparative anatomy and physiology of chemical senses in aquatic mammals . In “ Sensory Evolution on the Threshold Adaptations in Secondarily Aquatic Vertebrates ” ( J. G. M. Thewissen , and S. Nummela , eds ) , pp. 95 – 109 . University of Califor...
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Multiple sclerosis (MS) is a debilitating chronic inflammatory disease of the nervous system that affects approximately 2.3 million individuals worldwide, with higher prevalence in females, and a strong genetic component. While over 200 MS susceptibility loci have been identified in GWAS, the underlying mechanisms whereby they contribute to disease susceptibility remains ill-defined. Forward ge...
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Several hypotheses have been proposed to explain the direction and extent of sexual size dimorphism in anurans (in which males are usually smaller than females) as a result of sexual selection. Here, we present an analysis to test the hypothesis that sexual dimorphism in anurans is largely a function of differences between the sexes in life-history strategies. Morphological and demographic data...
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The embryonic gonad of Drosophila melanogaster begins to display sexually dimorphic traits soon after its formation. Here we demonstrate the involvement of a wnt family ligand, wnt-2, in the induction of these sex-specific differences. We show that wnt-2 contributes to the survival of a male-specific population of somatic gonadal precursor cells (SGPs), the male-specific SGPs that are located a...
متن کاملSexual dimorphism in innate immunity.
OBJECTIVE To establish whether variation in innate immunity, as measured by the level of tumor necrosis factor (TNF) in lipopolysaccharide (LPS)-stimulated whole-blood culture, is related to sex or HLA. METHODS Normal volunteers (72 women, 159 men) completed questionnaires and donated peripheral blood specimens. Blood samples were exposed to LPS in a 4-hour in vitro culture, and supernatants ...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2015
ISSN: 0021-9738
DOI: 10.1172/jci78082